Oocytes, eggs and blastomeres of the embryo are special cells that undergo rapid changes in structure and function at developmental transitions. These changes are frequently regulated by cytoplasmic signaling events, particularly at the developmental transition of fertilization, because the genome is largely inactivated at this time. Protein kinase C (PKC) is a signaling agent that acts after the sperm‐induced rise in calcium and has a central role in the remodeling of the structure of the egg into the zygote in many (...) species. PKC also acts during other developmental transitions. This kinase serves as a chronometer, which can choreograph the cell's remodeling events in both space and time. Several technical advancements discussed in this review have permitted a better understanding of the actions of PKC. (shrink)

Originally published in 1988, M. C. Dillon's classic study of Merleau-Ponty is now available in a revised second edition containing a new preface and a new ...

Empathy is an important human ability associated with successful social interaction. It is currently unclear how to optimally measure individual differences in empathic processing. Although the Big Five model of personality is an effective model to explain individual differences in human experience and behavior, its relation to measures of empathy is currently not well understood. Therefore, the present study was designed to investigate the relationship between the Big Five personality concept and two commonly used measures for empathy (Empathy Quotient (EQ), (...) Interpersonal Reactivity Index (IRI)) in four samples from China, Germany, Spain and the United States of America. This approach was designed to advance the way the Big Five personality model can be used to measure empathy. We found evidence of medium effect sizes for associations between personality and empathy, with agreeableness and conscientiousness as the most important predictors of affective and cognitive empathy (measured by the respective IRI subscales) as well as a for a one-dimensional empathy score (measured by the EQ). Empathy in a fictional context was most closely related to openness to experience while personal distress was first of all related to neuroticism. In terms of culture, we did not observe any distinct pattern concerning cultural differences. These results support the cross-cultural applicability of the Empathy Quotient and the Interpersonal Reactivity Index and indicate structurally similar associations between personality and empathy across cultures. (shrink)

What are the most fundamental features of the world? Do minds stand outside the natural order? Is a unified picture of mental and physical reality possible? The Mind in Nature provides a staunchly realist account of the world as a unified system incorporating both the mental and the physical.

Media increasingly accuse firms of exploiting suppliers, and these allegations often result in lurid headlines that threaten the reputations and therefore business successes of these firms. Neither has the phenomenon of supplier exploitation been investigated from a rigorous, ethical standpoint, nor have answers been provided regarding why some firms pursue exploitative approaches. By systemically contrasting economic liberalism and just prices as two divergent perspectives on supplier exploitation, we introduce a distinction of common business practice and unethical supplier exploitation. Since supplier (...) exploitation is based on power, we elucidate several levels of power as antecedents and investigate the role of ethical climate as a moderator. This study extends Victor and Cullen’s ethical climate matrix according to a supply chain dimension and is summarized in an integrated, conceptual model of five propositions for future theory testing. Results provide a frame of reference for executives and scholars, who can now delineate unethical exploitation and understand important antecedents of the phenomenon better. (shrink)

This critical interpretation shows Derridian thought to be permeated by a semiology that reduces all meaning to the signification of signs thus challenging the philosophy of deconstruction at its roots.

_Situates Merleau-Ponty’s thinking in the last decade of the twentieth century, both with regard to general context and specific themes._.

The development of a compositional model shows the incoherence of such notions as levels of being and both bottom-up and top-down causality. The mathematization of nature through the partial considerations of physics qua quantities is seen to lead to Pythagoreanism, if what is not included in the partial consideration is denied. An ontology of only probabilities, if not Pythagoreanism, is equivalent to a world of primitive dispositionalities. Problems are found with each. There is a need for properties as well as (...) quantities and these properties must be qualitative as well as dispositional. So there is a need for physical qualia (qualities) for the depiction of the intrinsic character of the finest interstices of nature. (shrink)

The author shows that the beliefs of Catholics and other Christians are reasonable, not based on blind faith. Drawing on Catholic and Christian theological traditions, the book links traditional teaching with contemporary issues to illustrate the relevance of faith to modern cultural, ethical, and scientific issues.--From publisher's description.

This work is an exceptionally rich account both of the connections and divergences between Levinas and Derrida as ethical thinkers. Against the backdrop of nineteenth and twentieth century philosophy and phenomenology, Srajek draws on Hermann Cohen's ethics of correlation so as to demonstrate how far it is possible to read Levinas and Derrida as constructing similar approaches to ethics.

'Why did the window break when it was hit by the stone? Because the window is brittle and the stone is hard; hardness and brittleness are powers, dispositional properties or dispositions.' Dispositions are essential to our understanding of the world. This book is a record of the debate on the nature of dispositions between three distinguished philosophers - D. M. Armstrong, C. B. Martin and U. T. Place - who have been thinking about dispositions all their working lives. Their (...) distinctive accounts cover many of the issues surrounding dispositions such as the nature of mind, matter, universals, existence, laws of nature and causation. Dispositions illuminates this central topic in analytic philosophy and at the same time highlights deeper concerns of metaphysics. (shrink)

IT IS SHOWN IN DETAIL THAT RECENT ACCOUNTS FAIL TO DISTINGUISH BETWEEN INTENTIONALITY AND MERELY CAUSALLY DISPOSITIONAL STATES OF INORGANIC PHYSICAL OBJECTS—A QUICK ROAD TO PANPSYCHISM. THE CLEAR NEED TO MAKE SUCH A DISTINCTION GIVES DIRECTION FOR FUTURE WORK. A BEGINNING IS MADE TOWARD PROVIDING SUCH AN ACCOUNT.

What are the most fundamental features of the world? Do minds stand outside the natural order? Is a unified picture of mental and physical reality possible? The Mind in Nature provides a staunchly realist account of the world as a unified system incorporating both the mental and the physical. C. B. Martin, an original and influential exponent of 'ontologically serious' metaphysics, echoes Locke's dictum that 'all things that exist are only particulars', and argues that properties are powerful qualities. He (...) also spells out the implications of this view for philosophical conceptions of causation, intentionality, consciousness, and the mind-body problem. Martin emphasizes the importance of non-conscious 'vegetative' systems, which provide clear examples of intentionality in the form of representational use. The slide from representational use to consciousness involves a change in the material of use, but not the form of representation. A concluding chapter provides an argument for the view that an ontology of particular substances and properties leads ineluctably to monism: the bus we board with Locke takes us directly to the world of Spinoza and Einstein. Along the way, we are led to understand the nature of minds and conscious states of mind in a way that avoids both reductionism and dualism. (shrink)

En el primer libro de su Ética Nicomaquea, Aristóteles hace dos intentos por establecer la tesis de que ser un ser humano tiene un punto, usando dos conjuntos paralelos de ejemplos. Su primer paso es sostener que siempre que algo tiene una actividad característica esa actividad es su fin, usando el ejemplo del “flautista, el escultor y, en general, cualquier artesano”. Esta identificación de la actividad característica de un artesano con la ubicación de su “bien y lo bueno” qua artesano (...) y, por ello, presumiblemente con el télos del artesano, podría ser cuestionada, por supuesto, pero esto no afecta el curso de los argumentos y el uso de los ejemplos que quiero perseguir. Es suficiente que, para ciertos roles dados, pueda haber una relación teleológica con algún punto para aquel rol. (shrink)

Merleau-Ponty and Derrida articulate two overlapping but divergent ways of thinking about differentiation, ecart and differance. This volume represents the viewpoints of fifteen leading North American scholars working in the fields of Continental philosophy, phenomenology, and postmodernism. In essays written expressly for this volume, these scholars address the matrix of thought underlying contemporary responses to postmodernism at large and deconstructionism in particular: identity and difference, community and alterity, self and other, metaphysics and its closure, language and its beyond, signification and (...) referentiality. (shrink)

In answering the question, “How is the concept of a person possible?”, Strawson lays great stress upon a particular class of predicate.He says, “They are predicates, roughly, which involve doing something, which clearly imply intention or a state of mind or at least consciousness in general, and which indicate a characteristic pattern, or range of patterns, of bodily movement, while not indicating at all precisely any very definite sensation or experience …. Such predicates have the interesting characteristic of many P-predicates, (...) that one does not, in general, ascribe them to oneself on the strength of observation, whereas one does ascribe them to others on the strength of observations. But, in the case of these predicates, one feels minimal reluctance to concede that what is ascribed in these two different ways is the same. This is because of the marked dominance of a fairly definite pattern of bodily movement in what they describe, and the marked absence of any distinctive experience. (shrink)

The Mind in Nature has two central aims. First, that of defending a ‘basic ontology’. Second, having advanced a plausible ontological framework, to appeal to it to cast light on the status of intentionality and the nature of consciousness, paying particular attention to the question of what distinguishes conscious systems from those that are vegetative.Central to Martin's basic ontology is his acceptance of a realist conception of dispositionality. Contrary to the view of David Lewis and others, talk about a (...) thing's dispositions cannot be analysed as talk about a thing's behaviour in a set of counterfactual circumstances. The account of dispositions that emerges from Martin's discussion is one according to which a specific disposition is either actual or it is not. To be actual a disposition need not be manifesting any manifestation. Unmanifesting dispositions are not, therefore, unactualized possibilia – a description which, he observes, is more fitting of unmanifested manifestations. In advancing a realist conception of dispositionality, Martin also opposes those who maintain that dispositional properties reduce to …. (shrink)

This invaluable resource demystifies the complex, rapidly changing, and sometimes confusing world of digital print technologies.

A simultaneous collision that produces paradoxical indeterminism (involving N0 hypothetical particles in a classical three-dimensional Euclidean space) is described in Section 2. By showing that a similar paradox occurs with long-range forces between hypothetical particles, in Section 3, the underlying cause is seen to be that collections of such objects are assumed to have no intrinsic ordering. The resolution of allowing only finite numbers of particles is defended (as being the least ad hoc) by looking at both -sequences (in the (...) context of a very basic supertask, in Section 4) and *-sequences (reversed -sequences, in the form of paradoxical results from the recent literature). Introduction The simultaneous collision The paradox in other contexts The basic problem is N0 things The recent literature Generating N0 things. (shrink)

The aim of this paper is to set out some of the ontologies amongst which some forms of anti-realism must select. This provides the appropriate setting for presenting an alternative realist ontology. The argument is that the choice between the varieties of anti-realism and realism is inevitably a choice between ontologies.

Professor Sir Joseph Rotblat made significant contributions to nuclear physics and worked on the development of the atomic bomb. He walked out of the Manhattan Project after working there for less than a year, the only scientist to do so. Rotblat gave a comprehensive account of his time at Los Alamos. His Archive is now becoming available and papers contained therein are inconsistent with some aspects of his account. The reasons as to how such anomalies and contradictions could occur are (...) considered. (shrink)